About Von Willebrand Disease — What is VWD
Humat-P for VWD — High-Quality VWF
Using Humate-P
Dosage Calculator
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Reimbursement and Prescribing Information
The CSL Behring Commitment
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Important Safety Information
Prescribing Information
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VWF Densitometric Analysis
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For Patients

Dosage Calculator

Dosage calculator

This unique Humate-P® Dosage Calculator makes individual dosing fast, easy, and convenient. The calculator determines the correct Humate-P® dose (as measured in VWF:RCo units) needed to achieve the desired increase in circulating VWF based on prescribing information. (To access the approved dosing, please use the full prescribing information)

To use the calculator, simply enter the patient’s weight, then select the desired absolute increase in circulating VWF. The correct dosage will appear in the results window. (These calculations are to be used only with Humate-P®and are applicable to all VWD types.)

Note: Doses are calculated based on an expected in vivo recovery of 1.5 IU/dL rise in VWF:RCo activity per every IU/kg of VWF:RCo administered.

Click here to view dosage calculator.


Important Safety Information

Antihemophilic Factor/von Willebrand Factor Complex (Human), Dried, Pasteurized, Humate-P® is indicated in adult patients for treatment and prevention of bleeding in hemophilia A (classical hemophilia). Humate-P® is also indicated in adult and pediatric patients with von Willebrand disease (VWD) for (1) treatment of spontaneous and trauma-induced bleeding episodes, and (2) prevention of excessive bleeding during and after surgery. This applies to patients with severe VWD, and patients with mild and moderate VWD for whom use of desmopressin is known or suspected to be inadequate.

Humate-P® is contraindicated in individuals with a history of anaphylactic or severe systemic response to antihemophilic factor or von Willebrand factor preparations or to any of its components.

Thromboembolic events have been reported in VWD patients receiving coagulation factor replacement, especially in the setting of known risk factors for thrombosis. Caution should be exercised and antithrombotic measures considered.

Humate-P® is derived from human plasma. As with all plasma-derived products, the risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent, cannot be completely eliminated.

Although few adverse reactions have been reported the most common are allergic-anaphylactic reactions, including urticaria, chest tightness, rash, pruritus, edema, shock, chills and fever, and hypervolemia. For patients undergoing surgery, the most common adverse reactions are postoperative wound or injection-site bleeding.

Please see accompanying full prescribing information for Humate-P®.

The information provided herein is solely for use by physicians and healthcare professionals in the United States. The CSL Behring product listed may not have been approved in other countries and may not be available everywhere.

References

  1. Kraaijenhagen RA, in‘t Anker PS, Koopman MMW, et al. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism.Thromb Haemost. 2000;83:5-9.